Las Cruces, also known as "The City of the Crosses", is the seat of Doña Ana County, New Mexico, United States. As of the 2010 census the population was 97,618, and in 2015 the estimated population was 101,643, making it the second largest city in the state, after Albuquerque. Las Cruces is the largest city in both Doña Ana County and southern New Mexico. The Las Cruces metropolitan area had an estimated population of 213,676 in 2014. It is the principal city of a metropolitan statistical area which encompasses all of Doña Ana County and is part of the larger El Paso–Las Cruces combined statistical area.Las Cruces is the economic and geographic center of the Mesilla Valley, the agricultural region on the floodplain of the Rio Grande which extends from Hatch to the west side of El Paso, Texas. Las Cruces is the home of New Mexico State University, New Mexico's only land-grant university.